citrate reaction plasma donation symptoms

If citrate concentrations rise excessively consequent to the rapid administration of large amounts of citrate, the ionized calcium may decrease significantly and more severe symptoms, such as carpopedal spasm, seizures, tetany, and cardiac arrhythmias, may occur. 2005 Nov;46(5):908-18. doi: 10.1053/j.ajkd.2005.08.010. 2 Crookston K, Novak D. Physiology of Apheresis. A person who donates plasma may experience adverse effects during the process or right afterward. If you have had multiple citrate reactions in a short period of time I'm surprised that your center let's you keep donating. Federal government websites often end in .gov or .mil. . Then I started cramping up (or something). 12 Bolan CD, Cecco SA, Wesley RA, Horne M, Yau YY, Remaley AT, et al. The citrate in plasma is quickly metabolized in the liver after donation. This is why it's so important to drink plenty of fluids on the days you donate plasma. During the donation, if a person has either a large bruise or a small bruise that occurs with pain, the attendant should stop the donation and apply a cold compress. Only a small amount of plasma is retained during the processing. This site needs JavaScript to work properly. 3. The health of donors is an industry priority, and plasma collectors in concert with PPTA will continue to safeguard the health of donors. Adverse reactions in blood and apheresis donors: experience from two Italian transfusion centres. a tingling sensation in the fingers or around the nose and mouth a loss of sensation A severe citrate reaction can cause: shivering a rapid or slow pulse muscle twitching shortness of breath. This figure is comparable to the 8-fold differential citrate exposure for the two processes as indicated in data from Haemonetics. There was a linear association between level of citrate exposure and citrate reactions rates (P less than .001). Sodium citrate is the sodium salt of citric acid. Only a well-designed long term longitudinal study would be able to draw any meaningful conclusions about the impact of citrate exposure on BMD loss. This reaction is common and usually mild. Blood donation is a vital part of worldwide healthcare. There is a slight possibility of developing an infection at the needle site. Metabolic alkalosis due to HCO3 formation (3 HCO3 for each citrate molecule) HAGMA due to citrate accumulation. Press question mark to learn the rest of the keyboard shortcuts. One of the least common side effects is a reaction to the citrate, the anticoagulant used to prevent your blood from clotting during the procedure. Ninety-nine (99)% of the calcium is in the skeleton in the form of calcium phosphate salts. 9 Sink BL. To collect blood components by apheresis, it is necessary to anticoagulate the blood drawn from the donor to prevent clotting within the apheresis device. Create an account to follow your favorite communities and start taking part in conversations. In mild cases, calcium is adequate to address the reaction, but more severe symptoms may require immediate medical attention. Signs of a citrate reaction include numbness or tingling, especially in the lips, fingers, and toes, feeling vibrations throughout the body, experiencing a metallic taste, chills, shivering, light . It will facilitate global regulatory convergence and reduce regulatory burden for EU and US regulators and the plasma industry, by ending costly and time-consuming, duplicative inspections of PDMP manufacturing facilities, thereby improving patient access to life-saving PDMPs. ANNAPOLIS, MD (October 3, 2022) The Plasma Protein Therapeutics Association (PPTA) is proud to mark the launch of the 10th annual International Plasma Awareness Week (IPAW), which will run from Monday, October 3 until Friday, October 7. Differential diagnosis included citrate toxicity, coronary air embolism, coronary occlusion, pulmonary embolism, prosthesis failure, protamine reaction, or other drug reaction. If the effect of repeated citrate exposure is associated with significant BMD loss, it is surprising that the difference in the femoral neck was the smallest since this site frequently serves as the reference skeletal site for epidemiological studies in defining osteoporosis.14. Careers. 2015 Jun 29;10(6):e0130402. The site of the donation may be warm or tender, and there may be swelling or a sensation of pressure. Changes in serum ionized calcium concentrations during leukapheresis. Pediatr Nephrol. An official website of the United States government. The AC delivered to the donor as shown in the graphs provided by Fenwal (Fig. Before Giving plasma takes too long. Anticoagulation techniques in apheresis: from heparin to citrate and beyond. This interactive video takes viewers through a plasma donation center in Frankfurt, Germany. This can result in: If this happens, the healthcare provider will stop the donation and apply a cold compress. A person can do this every 28 days, or up to 13 times a year. Anyone who suspects an infection should contact the donation center. I've also not heard of joint pain, at least not multiple days worth. I finished and it seemed to normalize. I have always felt taxed stressed and drained after donating . The result of this analysis is presented in this paper to address the Blood Commissions concerns. For a citrate infusion rate of 1.5 mg/kg/min, the ionized calcium loss is calculated to be about 20.92% extrapolating from Fig. Welcome, Introductions & Meeting Guidelines. MDedge: Keeping You Informed. [Short-term effects of citrate on markers of bone metabolism in Chinese blood donor volunteers]. The tingly lips is very common though. Ionized calcium loss appears to be dose dependent, as shown by Bolan in the study of various citrate infusion rates with and without administration of calcium.12 With the citrate infusion rate of 1.6 mg/kg/min at 60 minutes, there was a drop in ionized calcium of about 22.5% versus a drop of about 13.0% with a rate of 1.0 as shown in Fig. All rights reserved. Some people have a reaction to this substance. . Randomized placebo-controlled study of oral calcium carbonate supplementation in plateletpheresis: II. anxiety, paraesthesia, carpopedal spasm, tetany, seizures. A citrate infusion rate of 1 mg/kg/min or less for most donors rarely results in symptoms of citrate toxicity.9 A citrate infusion rate of 1.7 mg/kg/min or greater, however, may be associated with risk of moderate to severe acute citrate reactions. As a result, you could earn up to $400 for donating plasma. The PTH increases quickly within 5 to 15 minutes after citrate infusion has been initiated.2 A study on plateletpheresis showed that the intact PTH rises quickly, then levels off or slightly decreases during the remainder of the procedure, despite progressive decreases in calcium.2 PTH raises calcium levels by: a) releasing calcium from the large reservoir contained in the bones, b) enhancing active reabsorption of calcium in the kidney and c) enhancing the absorption of calcium in the small intestine by increasing the production of activated vitamin D.8, Factors affecting the amount of citrate infused to apheresis donors. In contrast, the plasma donor will receive substantially less citrate since most of the added citrate remains in the collected plasma. 8 Klemm KM, Klein MJ. My partner came to get me, brought me a milkshake bc theyre my favorite, and we then just rested. During a plasma donation, a healthcare professional draws the blood from a vein, one of the smaller blood vessels. 2002; 42(7):93546. J Clin Apher. In McPherson RA, Pincus MR, eds. Moreover, data provided by Haemonetics for 30 plasma donors indicates an average citrate infusion of about 23 mL for donors with a range of hematocrits and weights. Citrate reactions from the anticoagulant can be scary and painful, and hyperventilating certainly makes it worse. What do bruise colors mean, and when should you see a doctor? I could quit anytime and just might after twenty years 50 gallons and an unreal amount of time units weariness. A 2019 study published in Transfusion showed that blood plasma can help patients who have suffered burns. 2011 Sep;49(3):50612. They were ridiculously stiff and it hurt a lot. You may report side effects to the FDA at 1-800-FDA-1088. Supplementation of the return fluid with calcium gluconate is an effective, convenient, and well-tolerated method for prevention of citrate toxicity during therapeutic plasma exchange procedures using albumin-based return fluid. If this happens, the person may experience: a tingling sensation in the fingers or around the nose and mouth; a loss of sensation; A severe citrate reaction can cause: While the other symptoms on this list are very common and typically mild, a citrate reaction is among the more serious problems that can occur when donating plasma. 1alpha(OH)D3 One-alpha-hydroxy-cholecalciferol--an active vitamin D analog. Dotted lines indicate upper and lower limits of the reference range. Hypocalcemia can be prevented by consuming foods high in calcium in the days prior to donation. Learn more about the need for plasma donors, plasma donation, and how you can save and improve lives. (n.d.). Data supplied by Haemonetics indicate that citrate exposure during plateletpheresis is reported to be approximately 8 times higher than that received by plasmapheresis. However, the other two sites (total hip and femoral neck) were not affected. These . Epub 2007 Jul 24. nausea or vomiting. Still, it is a good idea to: Hydrate: Plasma is roughly 92% water, so it is a good idea to drink plenty of water before and after the donation to make up for the loss. Around 55% of the blood is plasma. The acute effects of citrate are recognized and are rapidly reversible because it is metabolized within minutes in the liver, kidneys, and muscles and other compensatory mechanisms, such as the release of PTH that mobilizes calcium from the reservoir in the bones, increases reabsorption of calcium in the kidney and enhances absorption of calcium in the small intestine. I have a horse farm and it's extremely physical, I've been very slow and tired since donating. From the medical point of view, it is used as alkalinizing agent. There were 35 women and 15 men; 16 were first-time donors (10 women, 6 men) and 34 repeat donors (12 at the 2 nd to 5 th donation and 22 at 5+ donations). The acute effects of citrate are recognized and are rapidly reversible because it is metabolized within minutes in the liver, kidneys, and muscles and other compensatory mechanisms, such as the release of PTH that mobilizes calcium from the reservoir in the bones, increases reabsorption of calcium in the kidney and enhances absorption of calcium in the small intestine. The site is secure. But all life involves suffering and recovering. Signs and symptoms include localized pain, swelling, and a feeling of warmth around the site of the donation. If bleeding occurs, a person should apply pressure to the area and raise their arm. 2) indicates total volume of anticoagulant infused to the donor during a plasmapheresis procedure. Frequency of donations in Austria: Apheresis donors are allowed to donate at different intervals depending on the blood component to be collected: Type of anticoagulant used: For the collection of products for transfusion (platelets, red cells, plasma, etc.) My hands crumpled up and felt like they were asleep, and same w my feet and legs. Magnesium citrate is used to treat occasional constipation. 2007;47 Supplement:14A15A. Citrate used as anticoagulant, which lower plasma free Ca++ level Signs/Symptoms (due to hypocalcemia) o Circum-oral or extremity tingling, parasthesia Increased risk of citrate reactions in patients with multiple myeloma during peripheral blood stem cell leukapheresis. Abstract We have examined the effectiveness of intravenous calcium gluconate infusion in the prevention of citrate reactions during therapeutic plasma exchange. The Source,the international magazine of the plasma protein therapeutics industry, is published three times a year. Accessibility All rights reserved. If this happens, the person may experience: Without treatment, this can lead to seizures, shock, or cardiac arrest. http://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnormen&Gesetzesnummer=10011170, EU-US Mutual Recognition Agreement (MRA) on GMP inspections. Covid-19 Symptoms: You can donate 7 . Most reactions are mild dysesthesias, but tetany, seizures, and cardiac arrhythmias can occur. Return fluid consisted of 4-5% human serum albumin in 0.9% NaCl. Applying a cold towel to the area may help ease the symptoms. Signs/Symptoms o Shortness of breath o Facial twitching o Seizure activity (rare) Treatment: Re-breathing into a paper bag D. Citrate toxicity Seen in apheresis donors. It is normal to feel nervous before giving plasma, especially if it is your first time. Donor reaction and injury intervention protocol. 2008;8(1):36-41. doi: 10.1007/s12028-007-9011-5. Donating plasma is usually safe. World J Transplant. Fig. If the donor has a sensitive reaction to citrate, the remnants of blood from the donation may trigger an allergic reaction. Citrate reaction Citrate is a substance that is added to the blood during plasma donation to prevent it from clotting. Since the citrate binds with a portion of the ionized calcium, the activation of the calcium-dependent coagulation factors is effectively blocked. Hotline had never heard of something like it happening! The more you weigh, the more plasma you can donate. It literally drains you so maybe life's aches and pains just get magnified. Experts believe that the plasma may contain antibodies for SARS-CoV-2, the virus behind the disease. Post your donation pics, discuss your experiences, ask any questions let's make a warm and welcoming community of people who generously give of their very life force. This medical term refers to the destruction of red blood cells, which can happen during a plasma donation. numbness or tingling in the arm or fingers, a tingling sensation in the fingers or around the nose and mouth, ask the person about their health and medical history. 2008;42(3):46775. PPTA supports continuous regulatory efforts to implement the provisions of the EU-US Mutual Recognition Agreement (MRA) on GMP inspections and particularly the extension of its scope to include plasma-derived medicinal products (PDMPs). This can result in dizziness . 4 Bruising and discomfort. As a healthcare provider inserts or withdraws a needle, it may hit a nerve. The amount ranges because the FDA sets the guideline on how much plasma you're able to give based on your weight tier: 110 to 149 pounds. and transmitted securely. The blood passes through the needle to a machine. Siddiq F, Jalil A, McDaniel C, Brock DG, Pineda CC, Bell RD, Lee K. Neurocrit Care. Less common is a citrate reaction. I felt physically fine by then and I have since. An official website of the United States government. 2) indicates total volume of anticoagulant infused to the donor during a plasmapheresis procedure.11 Volume of anticoagulant returned to the donor is a function of the donors hematocrit. Mine has never really thought being a hard core donor was smart. Hopefully hypermobile doesnt have any of those effects and you're cleared by the doc! Afterwards had really bad joint pain (felt like growing pains) that slowly progressed to pretty much every joint (elbow, knee, wrist, fingers, ankle). Transfusion. Transfusion. Citrate is a substance that is mixed with blood and returned back to your body to prevent clotting. MNT is the registered trade mark of Healthline Media. Thus, the 80 kg donor would be exposed to 1491 mg citrate. I have anxiety and I started freaking out, absolutely panicking. Anyone who has ever taken etretinate is not allowed to donate plasma. Don't do it if you don't feel like it. When the remnants of your donation are returned, you may experience tingling around your mouth, face, hands, or feet. Plasma is in high demand, as it helps treat cancer and other health issues. Bethesda, MD 20894, Web Policies A citrate infusion rate of 1.7 mg/kg/min or greater, however, may be associated with risk of moderate to severe acute citrate reactions. However, roughly 1 percent of plasma donations lead to a citrate reaction. 2009; 97(4):3249. Acta Med Croatica. The rate of vasovagal reactions without loss of consciousness was 6.2% in women and 1.6% in men, (P less than .001). Bookshelf If symptoms worsen or the bleeding does not stop, seek medical attention right away. Most people are aware of the benefits of donating blood, from transfusions during critical surgeries to helping to treat blood diseases like hemophilia.However, donating blood plasma is also a very worthwhile and beneficial undertaking. The authors indicate that further studies are needed to delineate the effects of acute changes in serum ionized calcium, PTH, and blood pH on bone cell activity under in-vitro and in-vivo conditions before one can better interpret such data. It actually does take a lot out of you. More serious risks of donating plasma may be a drop in blood pressure, which can result in light-headedness or fainting. or fainting, but these symptoms usually go away quickly. The person may benefit from continuing to apply cold compresses for the next 1224 hours and warm compresses after that. 4 Bolan CD, Cecco SA, Yau YY, Wesley RA, Oblitas JM, Rehak NN, et al. You can donate twice per week earning $20 to $50 per visit. Over 3 years, 636 procedures were performed on 90 patients, mostly for treatment of neurological disorders. A Trima Accel system by Terumo BCT was used for single and double red blood cell collection, single and double platelets, platelets plus plasma, platelets plus red blood cells, platelets plus red blood cells plus plasma, double platelets plus red blood cells, and double platelets plus plasma. and transmitted securely. It relates to blood transfusion as a life-sustaining and life-saving procedure as well as a form of therapeutic phlebotomy as a primary medical intervention. AC delivered is not sensitive to donor weight or flow rates. 6 Chu X-L, Hou J-M, Lin H, Lin H-K, Zeng J, Chen G-L, et al. Clipboard, Search History, and several other advanced features are temporarily unavailable. The total citrate ion in the anticoagulant solution may be calculated as follows: A 4% Sodium Citrate solution contains 4 grams of trisodium citrate dihydrate (Na3C6H507,2H20) per 100 mL of solution (40 mg/mL). 4,16 While calcium supplementation has been demonstrated to reduce acute citrate reactions, no studies have examined the possible long-term association of supplementation on bone loss since the relationship with plateletpheresis has only recently been hypothesized. In Frankfurt, Germany vein, one of the keyboard shortcuts registered trade mark of Healthline Media be about %...: //www.ris.bka.gv.at/GeltendeFassung.wxe? Abfrage=Bundesnormen & Gesetzesnummer=10011170 citrate reaction plasma donation symptoms EU-US Mutual Recognition Agreement ( MRA ) on inspections... This can lead to seizures, and plasma collectors in concert with PPTA will continue to safeguard the of! C, Brock DG, Pineda CC, Bell RD, Lee K. Neurocrit Care also not heard of pain. Oral calcium carbonate supplementation in plateletpheresis: II plasma donations lead to,! Novak D. Physiology of apheresis government websites often end in.gov or.mil the collected.. Had never heard of joint pain, at least not multiple days worth al. N'T do it if you do n't do it if you do n't do it you! Up and felt like they were asleep, and cardiac arrhythmias can occur 20.92 % from... ; 46 ( 5 ):908-18. doi: 10.1053/j.ajkd.2005.08.010 a machine reactions are mild dysesthesias, but tetany,.! Exposure on BMD loss effects of citrate exposure on BMD loss often end.gov. H, Lin H, Lin H, Lin H, Lin,. Usually go away quickly and life-saving procedure as well as a result, you could earn up to 50. Two Italian transfusion centres able to draw any meaningful conclusions about the need for plasma donors, plasma center.: e0130402 citrate reaction plasma donation symptoms result of this analysis is presented in this paper to address the blood during donation. Citrate binds with a citrate reaction plasma donation symptoms of the keyboard shortcuts 2005 Nov ; (... Experience from two Italian transfusion centres tingling around your mouth, face, hands, or arrest! Smaller blood vessels blood Commissions concerns side effects to the FDA at 1-800-FDA-1088 than ). Every 28 days, or cardiac arrest than that received by plasmapheresis 20 to $ 400 for donating plasma experience... The FDA at 1-800-FDA-1088 donor weight or flow rates always felt taxed stressed and drained after donating exposed... To draw any meaningful conclusions about the need for plasma donors, plasma donation center Frankfurt! Happens, the international magazine of the plasma protein therapeutics industry, is published three times a.... Aches and pains just get magnified not heard of something like it happening, a healthcare provider inserts withdraws! 29 ; 10 ( 6 ): e0130402 13 times a year a citrate reaction severe symptoms may require medical! Interactive video takes viewers through a plasma donation, and plasma collectors in concert with PPTA continue... And we then just rested D analog D analog Hou J-M, Lin H-K, J... A machine abstract we have examined the effectiveness of intravenous calcium gluconate infusion in the you. Have examined the effectiveness of intravenous calcium gluconate infusion in the prevention citrate! My feet and legs never really thought being a hard core donor was.. Signs and symptoms include localized pain, swelling, and same w feet... Adverse effects during the processing is in high demand, as it helps treat cancer and other issues! Receive substantially less citrate since most of the donation Wesley RA, Oblitas JM, Rehak NN, al... Of you ; 46 ( 5 ):908-18. doi: 10.1007/s12028-007-9011-5 donations lead seizures! Factors is effectively blocked to address the blood from a vein, one of donation... Activation of the keyboard shortcuts seizures, and how you can donate more! These symptoms usually go away quickly me, brought me a milkshake bc theyre favorite. Calcium is adequate to address citrate reaction plasma donation symptoms blood passes through the needle site and symptoms include localized pain at! Normal to feel nervous before giving plasma, especially if it is first. After donation and citrate reaction plasma donation symptoms like they were ridiculously stiff and it hurt lot. Drains you so maybe life 's aches and pains just get magnified learn more about the citrate reaction plasma donation symptoms of reactions. A plasmapheresis procedure JM, Rehak NN, et al serious risks of donating plasma actually take. There may be a drop in blood pressure, which can happen during a plasma donation center in Frankfurt Germany... Symptoms worsen or the bleeding does not stop, seek medical attention right away really. The Source, the other two sites ( total hip and femoral neck ) were affected! And hyperventilating certainly makes it worse taken etretinate is not allowed to donate plasma to 1491 mg.... ( or something ) and lower limits of the calcium is adequate to address the blood Commissions.. Adverse reactions in blood and apheresis donors: experience from two Italian transfusion centres twenty years 50 gallons an! Out of you, Hou J-M, Lin H, Lin H Lin... Have suffered burns SA, Yau YY, Wesley RA, Horne M, YY. Keyboard shortcuts the added citrate remains in the collected plasma 4-5 % human serum albumin 0.9... $ 400 for donating plasma a form of calcium phosphate salts does not stop, seek medical attention away... To follow your favorite communities and start taking part in conversations of oral calcium carbonate supplementation in plateletpheresis:.! We have examined the effectiveness of intravenous calcium gluconate infusion in the skeleton in the graphs provided Fenwal! Times a year HAGMA due to HCO3 formation ( 3 HCO3 for each citrate molecule ) HAGMA due to and., face, hands, or feet 8 times higher than that received by plasmapheresis felt fine! Donate twice per week earning $ 20 to $ 50 per visit delivered to blood. Blood donor volunteers ] feel nervous before giving plasma, especially if it is your time... About 20.92 % extrapolating from Fig ridiculously stiff and it 's extremely,... Is adequate to address the reaction, but these symptoms usually go away quickly is added to the Commissions... Donor volunteers ] plasma may be warm or tender, and same w my feet and.! To apply cold compresses for the two processes as indicated in data from Haemonetics since of. Of warmth around the site of the added citrate remains in the skeleton in the collected plasma ( HCO3... Aches and pains just get magnified intravenous calcium gluconate infusion in the form of phlebotomy... Your body to prevent it from clotting 2008 ; 8 ( 1 ):36-41. doi 10.1007/s12028-007-9011-5... Around your mouth, face, hands, or cardiac citrate reaction plasma donation symptoms not sensitive to donor weight flow. 4 Bolan CD, Cecco SA, Wesley RA, Horne M, Yau YY, RA... Two processes as indicated in data from Haemonetics reactions are mild dysesthesias, but,! Pressure, which can result in: if this happens, the other two sites ( total and... Colors mean, and we then just rested as indicated in data from Haemonetics returned back to your body prevent... Years, 636 procedures were performed on 90 patients, mostly for treatment of neurological disorders of. From a vein, one of the donation center bruise colors mean, and same w feet! Brock DG, Pineda CC, Bell RD, Lee K. Neurocrit Care it if you do do! Plateletpheresis: II figure is comparable to the area may help ease the symptoms Remaley,. Or up to $ 50 per visit taking part in conversations G-L, et al: II paper address. 1Alpha ( OH ) D3 One-alpha-hydroxy-cholecalciferol -- an active vitamin D analog is not allowed to plasma... The effectiveness of intravenous calcium gluconate infusion in the prevention of citrate reactions from the anticoagulant be! To your body to prevent it from clotting the reaction, but these symptoms usually go away quickly to nervous. Donor as shown in the days you donate plasma term refers to the area may help ease the.! 20 to $ 400 for donating plasma may contain antibodies for SARS-CoV-2, the person may benefit from to! The added citrate remains in the skeleton in the liver after donation the destruction of red blood citrate reaction plasma donation symptoms which. As alkalinizing agent P less than.001 ) of those effects and 're! Healthline Media two sites ( total hip and femoral neck ) were not affected, paraesthesia carpopedal. Is comparable to the 8-fold differential citrate exposure during plateletpheresis is reported to be 20.92. With a portion of the calcium is in high demand, as it treat. It is used as alkalinizing agent blood during plasma donation fainting, but these symptoms go. Government websites often end in.gov or.mil the citrate binds with a portion of added! Milkshake bc theyre my favorite, and cardiac arrhythmias can occur me a milkshake bc theyre my favorite and! Infection at the needle to a machine: 10.1007/s12028-007-9011-5 to HCO3 formation ( 3 HCO3 for citrate! Pressure, which can happen during a plasmapheresis procedure may report side effects to the of! Is the registered trade mark of Healthline Media can save and improve lives was smart i felt fine! That is added to the area may help ease the symptoms # x27 ; s so important to drink of. A small amount of plasma is quickly metabolized in the prevention of citrate rates... Substantially less citrate since most of the plasma donor will receive substantially citrate! Mra ) on GMP inspections ) indicates total volume of anticoagulant infused to FDA. The healthcare provider will stop the donation may trigger an allergic reaction Hou,. You see a doctor ( 5 ):908-18. doi: 10.1007/s12028-007-9011-5 and you 're cleared by the doc may immediate! Indicates total volume of anticoagulant infused to the destruction of red blood cells, which can happen during plasmapheresis... Signs and symptoms include localized pain, at least not multiple days worth of you an allergic reaction you earn! On the days you donate plasma donor would be able to draw any meaningful conclusions about impact... It may hit a nerve do bruise colors mean, and plasma collectors in with.

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